Description:

Activated B12 and Metafolin^® folate for methylation, energy, and nervous system health*

B-12 Folate delivers methylcobalamin and Metafolin^® L-5-MTHF in one capsule—activated forms that bypass common conversion steps practitioners prioritize for methylation, energy, and homocysteine support.*

B12 and folate work as cofactors in the same biochemical pathways. Pairing bioactive forms helps avoid masking B12 deficiency with unmetabolized folic acid while supporting red blood cell formation and neurological function.*

Product highlights

• 1,000 mcg methylcobalamin (activated B12)‡
• 1,000 mcg Metafolin^® L-5-MTHF bioactive folate‡
• Supports methylation, homocysteine balance, and nervous system health‡
• Hypoallergenic capsule suitable for MTHFR-sensitive protocols‡

Who is this for

B-12 Folate suits adults who need activated B-vitamin repletion:*

• Individuals with documented low B12 or folate under practitioner supervision.*
• Clients with MTHFR variants who benefit from L-5-MTHF instead of folic acid.*
• Vegetarians and older adults whose B12 absorption may be reduced.*
• Anyone separating B12/folate from a multi for precise dosing.*
• Sensitive patients who require Pure Encapsulations hypoallergenic standards.*

The Pure Encapsulations Difference

Pure Encapsulations formulates for sensitive patients: hypoallergenic ingredients, verifiable science, and manufacturing in NSF-GMP-registered facilities.

Metafolin^® and methylcobalamin in a single-ingredient capsule without hidden soy, gluten, or artificial preservatives.

Ingredients & supplement facts

Net wt 60 capsules · 60 servings (1 capsule per serving)

Suggested use

• Take 1 capsule daily, with a meal, or as directed by your healthcare professional.
• Review total B12 and folate from all supplements to avoid excessive intake.
• Have homocysteine, B12, and folate levels monitored when on repletion protocols.
• Store in a cool, dry place with the lid tightly closed.
• If pregnant or lactating, consult your physician before use.

Science & Research

Vitamin B12 and folate are essential for DNA synthesis, red blood cell formation, and homocysteine metabolism. Methylcobalamin and L-5-MTHF are bioactive forms commonly selected in clinical nutrition.

Frequently asked questions

What is Metafolin^®?

Metafolin^® is a patented form of L-5-methyltetrahydrofolate (L-5-MTHF)—a bioactive folate that bypasses the MTHFR conversion step required by folic acid.

Methylcobalamin vs cyanocobalamin?

Methylcobalamin is an activated B12 form already in a usable coenzyme state. Many practitioners prefer it for repletion protocols.

Can I take this with O.N.E. Multivitamin?

O.N.E. already includes B12 and folate. Use standalone B-12 Folate only when your clinician targets higher doses than a multi provides.

Is this suitable for vegetarians?

Yes. Capsules are vegetarian and hypoallergenic.

How long does one bottle last?

One capsule daily equals a 60-day supply per 60-capsule bottle.